Search Health-Diet-Alternative-Medicine-Info Article Directory:

Home | Cancer

Click the XML Icon Above to Receive Cancer Articles Via RSS!

Print This Article

 Post Comment Add To Favorites Email to Friends Ezine Ready

Faces of DARPP-32: Master Signaling Mediator in the Brain?
By: Stephen Jones

As a major target for dopamine-activated adenylyl cyclase and protein kinase A in the striatum, DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission and can act either as a phosphatase or kinase inhibitor in a contextually dependent manner. Growing evidence points to DARPP-32 as a key mediator/modulator in numerous signal transduction cascades implicated in a growing number of neurological disorders such as schizophrenia and depression, as well as in drug abuse and addiction. For example, it has been shown that acute exposure of mice to cocaine increases phosphorylation of DARPP-32 at Thr34 with a concommitment decrease in phosphorylation at Thr75, whereas chronic exposure leads to a reversal of this phospho profile. It has also been observed that many schizophrenic patients show decreased levels of DARPP-32 in the prefrontal cortex.

While the precise role that DARPP-32 plays in these psychiatric disorders is still being elucidated, the existing body of literature clearly portrays DARPP-32 as playing a central role in multiple signaling pathways. Further research will determine neuronal subpopulations where phosphorylation of DARPP-32 occurs as well as the functional importance of previously identified phospho sites of DARPP-32.

IMGENEX offers over one-thousand Neuroscience-related antibodies such as recently cited anti-DARPP-32 (pan and phosphospecific), Dopamine D1 and D2 Receptors (IHC validated), 5-HT Receptors (such as 5-HT1B), Adenosine Receptor, NMDA and more!

Article Source: http://health-diet-alternativemedicine-info.co.uk/health_articles

IMGENEX India Pvt Ltd. the only biotech company in Orissa and one of its kinds in Eastern India. IMGENEX India started in Oct as an outsourcing branch of IMGENEX Corporation, San Diego, USA. Find out more information about DARPP-32.

Please Rate this Article

Not yet Rated

Additional Articles From - Home | Cancer
Sitemap
Sign Up for a free account or learn more.
Natural Remedy Resources!
Health-Diet-Alternative-Medicine-Info
Submit Articles
Member Login
Top Authors
Most Popular Articles
Submission Guidelines
Ezine Notifications
Article RSS Feeds
A Viable Pay Per Click Alternative
Have you looked at the Pay-Per-Click prices these days? Ouch!

Free Targeted Ad Exchange Alternative
This is a high quality network that works much like AdWords and AdSense (only it's a lot easier).

Traffic Driving Program
We take the traffic building features of a banner exchange and the ease of text and put them together.
Top 10 Articles:

Get a copy of this script for your Dashboard directory.
Niche Article Generator
Instantly Creates Attention Grabbing And Profit Producing Niche Articles In Minutes And With Little To No Effort..
CLICK HERE TO GET NICHE ARTICLE GENERATOR TODAY!

Download your own article directory for FREE today!
Partners Article Directories
Health E-Books Store Restocking
About Us
Site Blog
Health Forum
Health Links/Link to Us
Contact Us
Privacy Policy
Terms of Service

Affiliate Classroom, For More Traffic Affiliate and Sales Classroom
The magazine about building an affiliate business...not just small checks
Newbie Survival Tactics, Startup Budget, Smart ROI, First Site Tips, Staying Sane.



Copyright 2005 by www.cjpwebdesign.co.uk Affordable Web Sites Designed

Powered by Article Dashboard